The S2C Handbook serves as a comprehensive guidebook and reference for efficient design and installation of post-installed anchors in Steel-to-concrete applications. It covers the basic understanding of structural connections, loadings, different parameters influence the performance of anchors addressing the need of post-installed systems in construction industry. This Guidebook helps the engineers to design and contractors to better install post-installed systems. It includes state-of-the-art design procedures including principles of product qualification for static, seismic, fire, and fatigue loads based on the Indian and European Guidelines (IS 1946 Part 2, Part 3 & part 4 and EN / EAD). The handbook provides step-by-step design calculation examples for all and how the design software PROFIS Engineering can be used for efficiently solving the design cases. A chapter is dedicated to the installation of post-installed anchors including the best procedures and tools used for the correct execution methods. This will help the designers/engineers to understand, specify, and implement design solutions. Some reference project examples from different parts of the globe which were made possible by implementing Hilti’s qualified solutions, are also showcased.